ea0049ep998 | Pituitary - Clinical | ECE2017
Selfa Silvia Maria Maraver
, Vega Maria Molina
, Molero Inmaculada Gonzalez
, Doblas Isabel Mancha
, Madueno Francisco Tinahones
Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...